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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">CCL8</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_CCL8" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">CCL8
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<td colspan="3"><span typeof="mw:File"></span>
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<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ESR">1ESR</a>
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<td>Andere Namen
</td>
<td colspan="2">
<p>Chemokine (C-C Motif) Ligand 8
</p>
<ul><li>SCYA8</li>
<li>Small Inducible Cytokine Subfamily A (Cys-Cys), Member 8 (Monocyte Chemotactic Protein 2)</li>
<li>Monocyte Chemoattractant Protein 2</li>
<li>Monocyte Chemotactic Protein 2</li>
<li>SCYA10</li>
<li>HC14</li>
<li>C-C Motif Chemokine 8</li></ul>
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<td colspan="3" class="hintergrundfarbe1" style="font-size:smaller;">
<p>Vorhandene Strukturdaten: <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1ESR">1ESR</a></span>
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<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
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<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
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<td colspan="2" style="text-align:center;">99 Aminosäuren, 11246 Da
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td>Externe IDs
</td>
<td colspan="2" class="">
<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCL8">CCL8</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/602283">602283</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P80075">P80075</a></li></ul>
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<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
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<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
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<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P80075">Hovergen</a>
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</tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>CCL8</b> (<span style="font-style:normal;font-weight:normal"><a href="Englische_Sprache" title="Englische Sprache">englisch</a></span> <span lang="en-Latn" style="font-style:italic"><i>CC-chemokine ligand 8</i></span>) ist ein <a href="Zytokin" title="Zytokin">Zytokin</a> aus der Familie der CC-<a href="Chemokin" title="Chemokin">Chemokine</a>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>CCL8 ist an <a href="Entz%C3%BCndung" title="Entzündung">Entzündungsprozessen</a> beteiligt. Es ist <a href="Chemotaxis" title="Chemotaxis">chemotaktisch</a> für und aktiviert verschiedene <a href="Immunzelle" class="mw-redirect" title="Immunzelle">Immunzellen</a>, darunter <a href="Mastzelle" title="Mastzelle">Mastzellen</a>, <a href="Eosinophile" class="mw-redirect" title="Eosinophile">Eosinophile</a> und <a href="Basophil" class="mw-redirect" title="Basophil">Basophile</a>, <a href="Monozyt" title="Monozyt">Monozyten</a>, <a href="T-Zelle" class="mw-redirect" title="T-Zelle">T-Zellen</a> und <a href="NK-Zelle" title="NK-Zelle">NK-Zellen</a>.<sup id="cite_ref-pmid8558070_1-0" class="reference"><a href="#cite_note-pmid8558070-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Gong_1998_2-0" class="reference"><a href="#cite_note-Gong_1998-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> CCL8 bindet an die <a href="Chemokinrezeptor" class="mw-redirect" title="Chemokinrezeptor">Chemokinrezeptoren</a> <a href="CCR1" title="CCR1">CCR1</a>, CCR2B und <a href="CCR5" title="CCR5">CCR5</a>.<sup id="cite_ref-Gong_1998_2-1" class="reference"><a href="#cite_note-Gong_1998-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Aufgrund der Bindung an den <a href="Korezeptor" title="Korezeptor">Korezeptor</a> des <a href="HIV" title="HIV">HIV</a>-1, CCR5, hemmt CCL8 eine Infektion von Zellen mit HIV-1.<sup id="cite_ref-pmid11087354_3-0" class="reference"><a href="#cite_note-pmid11087354-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-pmid8558070-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid8558070_1-0">↑</a></span> <span class="reference-text">Proost P, Wuyts A, Van Damme J: <cite style="font-style:italic">Human monocyte chemotactic proteins-2 and -3: structural and functional comparison with MCP-1</cite>. In: <cite style="font-style:italic">J. Leukoc. Biol.</cite> 59. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, Januar 1996, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>67–74</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/8558070?dopt=Abstract">PMID 8558070</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:CCL8&rft.atitle=Human+monocyte+chemotactic+proteins-2+and+-3%3A+structural+and+functional+comparison+with+MCP-1&rft.au=Proost+P%2C+Wuyts+A%2C+Van+Damme+J&rft.date=1996-01&rft.genre=journal&rft.issue=1&rft.jtitle=J.+Leukoc.+Biol.&rft.pages=67-74&rft.pmid=8558070&rft.volume=59.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-Gong_1998-2"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Gong_1998_2-0">a</a></sup> <sup><a href="#cite_ref-Gong_1998_2-1">b</a></sup></span> <span class="reference-text">Gong W, Howard OM, Turpin JA, Grimm MC, Ueda H, Gray PW, Raport CJ, Oppenheim JJ, Wang JM: <cite style="font-style:italic">Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication</cite>. In: <cite style="font-style:italic">J. Biol. Chem.</cite> 273. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>8</span>, Februar 1998, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>4289–92</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1074/jbc.273.8.4289">10.1074/jbc.273.8.4289</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/9468473?dopt=Abstract">PMID 9468473</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:CCL8&rft.atitle=Monocyte+chemotactic+protein-2+activates+CCR5+and+blocks+CD4%2FCCR5-mediated+HIV-1+entry%2Freplication&rft.au=Gong+W%2C+Howard+OM%2C+Turpin+JA%2C+...&rft.date=1998-02&rft.doi=10.1074%2Fjbc.273.8.4289&rft.genre=journal&rft.issue=8&rft.jtitle=J.+Biol.+Chem.&rft.pages=4289-92&rft.pmid=9468473&rft.volume=273.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-pmid11087354-3"><span class="mw-cite-backlink"><a href="#cite_ref-pmid11087354_3-0">↑</a></span> <span class="reference-text">J. Blaszczyk, E. V. Coillie, P. Proost, J. V. Damme, G. Opdenakker, G. D. Bujacz, J. M. Wang, X. Ji: <i>Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors.</i> In: <i>Biochemistry.</i> Band 39, Nummer 46, November 2000, S. 14075–14081, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11087354?dopt=Abstract">PMID 11087354</a>.</span>
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